Many spread offense's are pumping more and more rushing yards out of their athletic quarterback's (QB's). One of the simplest, yet effective plays out of the shot-gun is the QB Sweep (see diagram #1 above). This is also a great play to put in with your Tailback (TB) because it allows him to do what he is used to doing.
The QB will simply read the block of the #3 receiver (or inside slot). If the they get the hook he will sweep outside. If they kick-out, the QB will cut up and inside the block.
If you really want to keep the defense honest, compliment the QB sweep with the inside slot counter trap (see diagram #2 above). This could be either an inside hand-off or flip (schuffle) toss.